Principle Investigator

Introduction

Technological advances, many fueled by the Human Genome Project, have allowed the collection of biological data at an ever increasing pace. This phenomena is most apparent in the vast amounts of genomic sequence, transcript sequence, and gene expression data that is rapidly accumulating for not only human, but a growing number of organisms.

While this vast amount of information does immediately lend itself to a better understanding of some biological issues, the overall rate of technical advances is quickly outpacing the research community’s ability to interpret and understand these data. The goal of my research is to develop and/or utilize the techniques and tools necessary to assign functional roles to genes in a high-throughput fashion, with a focus on transcriptional regulatory networks involved in cardiovascular development.

Although the cardiovascular system is the first functional system to form during embryonic development, very little is currently known about the molecular processes required for this formation. Our current projects aim to identify and better understand the genes involved in the development of the vertebrate heart and vasculature. Our lab conducts experiments primarily on the embryos of the South African Clawed Frog (Xenopus laevis), but will also exploit the genetic potential of zebrafish (Danio rerio), and Xenopus tropicalis as needed.

Positions

• Assistant Professor, Indiana University School of Medicine
• Assistant Graduate Advisor, Dept. of Biochemistry and Molecular Biology
• Director of Custom Microarray Facility, Center for Medical Genomics
• Member, Executive Committee, Indiana Biocomplexity Institute
• Member, Indiana Center for Vascular Biology and Medicine
• Member, Center for Regenerative Biology and Medicine
• Member, Society for Developmental Biology

Contact Information

email: mgrow@iupui.edu

phone: 317-274-3399